Molecular mechanisms of external genitalia development
نویسندگان
چکیده
منابع مشابه
Growth and Development of Male External Genitalia
Results: Testes did not show any increase in size until theonsetofpubertyat age11years,whereaspenilegrowth was gradual after birth. However, both penile and testicular development demonstrated peak growth from 12 to 16 years of age, which coincided with the maximal male pubertal growth spurt. Data indicate an earlier pubertal development for this study population than that for a similar populat...
متن کاملDevelopment of the external genitalia: conserved and divergent mechanisms of appendage patterning.
Over the past decade, the genetics of external genital development have begun to be understood. Male and female external genitalia develop from the genital tubercle. The early tubercle has a superficial resemblance to the limb bud, but an important distinction is that the limb consists of only mesoderm and ectoderm, whereas the genital tubercle also has an endodermal component, the urethral epi...
متن کاملMolecular and genetic regulation of testis descent and external genitalia development.
Testicular descent as a prerequisite for the production of mature spermatozoa and normal external genitalia morphogenesis, and therefore facilitating copulation and internal fertilization, are essential developmental steps in reproduction of vertebrate species. Cryptorchidism, the failure of testis descent, and feminization of external genitalia in the male, usually in the form of hypospadias, ...
متن کاملUnique functions of Sonic hedgehog signaling during external genitalia development.
Coordinated growth and differentiation of external genitalia generates a proximodistally elongated structure suitable for copulation and efficient fertilization. The differentiation of external genitalia incorporates a unique process, i.e. the formation of the urethral plate and the urethral tube. Despite significant progress in molecular embryology, few attempts have been made to elucidate the...
متن کاملEvolution of external genitalia: insights from reptilian development.
External genitalia are found in each of the major clades of amniotes. The phallus is an intromittent organ that functions to deliver sperm into the female reproductive tract for internal fertilization. The cellular and molecular genetic mechanisms of external genital development have begun to be elucidated from studies of the mouse genital tubercle, an embryonic appendage adjacent to the cloaca...
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ژورنال
عنوان ژورنال: Differentiation
سال: 2012
ISSN: 0301-4681
DOI: 10.1016/j.diff.2012.06.003